2(S)-(2-Hydroxymethyl-morpholin-4-yl)-thiazol-4-one → 2-[(2S)-2-(Hydroxymethyl)morpholin-4-yl]-5-[(1-{[3-(trifluoromethyl)pyridin-2-yl]methyl}-1H-indazol-5-yl)methylidene]-1,3-thiazol-4(5H)-one

HRID 2384857Notes

Reaction equation

HRID 2384857 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[C:4]([CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([CH:19]=O)=[CH:16][CH:17]=3)[CH:12]=[N:11]2)=[N:5][CH:6]=[CH:7][CH:8]=1.[OH:23][CH2:24][C@H:25]1[O:30][CH2:29][CH2:28][N:27]([C:31]2[S:32][CH2:33][C:34](=[O:36])[N:35]=2)[CH2:26]1>>[OH:23][CH2:24][C@H:25]1[O:30][CH2:29][CH2:28][N:27]([C:31]2[S:32][C:33](=[CH:19][C:15]3[CH:14]=[C:13]4[C:18](=[CH:17][CH:16]=3)[N:10]([CH2:9][C:4]3[C:3]([C:2]([F:22])([F:1])[F:21])=[CH:8][CH:7]=[CH:6][N:5]=3)[N:11]=[CH:12]4)[C:34](=[O:36])[N:35]=2)[CH2:26]1

Participants

3

Reactant 2

HCID 672406872(S)-(2-Hydroxymethyl-morpholin-4-yl)-thiazol-4-oneHCID 866546281-(3-Trifluoromethyl-pyridin-2-ylmethyl)-1H-indazole-5-carbaldehyde

Product 1

HCID 672400992-[(2S)-2-(Hydroxymethyl)morpholin-4-yl]-5-[(1-{[3-(trifluoromethyl)pyridin-2-yl]methyl}-1H-indazol-5-yl)methylidene]-1,3-thiazol-4(5H)-one

Procedure

2-[(2S)-2-(Hydroxymethyl)morpholin-4-yl]-5-[(1-{[3-(trifluoromethyl)pyridin-2-yl]methyl}-1H-indazol-5-yl)methylidene]-1,3-thiazol-4(5H)-one was prepared from 1-(3-Trifluoromethyl-pyridin-2-ylmethyl)-1H-indazole-5-carbaldehyde and 2(S)-(2-Hydroxymethyl-morpholin-4-yl)-thiazol-4-one following General Procedure D.

Sources & evidence

ORD record
ord-ddb2e328be8f4078a5f8835ad7d97b89
Source dataset
uspto-grants-2012_09
Patent number
US08263781B2

Reaction notes

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