2(S)-(2-Hydroxymethyl-morpholin-4-yl)-thiazol-4-one → 2-[(2S)-2-(Hydroxymethyl)morpholin-4-yl]-5-[(1-{[3-(trifluoromethyl)pyridin-2-yl]methyl}-1H-indazol-5-yl)methylidene]-1,3-thiazol-4(5H)-one

Participants

Role	Name	HCID	Charge
Reactant	2(S)-(2-Hydroxymethyl-morpholin-4-yl)-thiazol-4-one	HCID 67240687	—
Reactant	1-(3-Trifluoromethyl-pyridin-2-ylmethyl)-1H-indazole-5-carbaldehyde	HCID 86654628	—
Product	2-[(2S)-2-(Hydroxymethyl)morpholin-4-yl]-5-[(1-{[3-(trifluoromethyl)pyridin-2-yl]methyl}-1H-indazol-5-yl)methylidene]-1,3-thiazol-4(5H)-one	HCID 67240099	—

Reaction Steps

2-[(2S)-2-(Hydroxymethyl)morpholin-4-yl]-5-[(1-{[3-(trifluoromethyl)pyridin-2-yl]methyl}-1H-indazol-5-yl)methylidene]-1,3-thiazol-4(5H)-one was prepared from 1-(3-Trifluoromethyl-pyridin-2-ylmethyl)-1H-indazole-5-carbaldehyde and 2(S)-(2-Hydroxymethyl-morpholin-4-yl)-thiazol-4-one following General Procedure D.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08263781B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-ddb2e328be8f4078a5f8835ad7d97b89
Source note	uspto-grants-2012_09