Hydrochloric Acid → 2-Methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid

Participants

Reaction Steps

Dissolve 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid methyl ester (0.2274 g, 0.54 mmol) in dioxane (10 mL) and add lithium hydroxide monohydrate (124 mg, 2.69 mmol) followed by water (5 mL). Stir the reaction at RT overnight, dilute with water (10 mL), and acidify with 1 N HCl. Collect the solid by filtration and wash with water (2×10 mL) and Et2O (2×10 mL). Dry the solid in a vacuum oven to give 0.145 g (66%). LC-MS/ES m/z 410.3 [M+H]+.

Provenance & Evidence