反应详情

Dissolve 2-methoxy-4-[2-(4-methoxy-phenyl)-7-oxo-4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl]-benzoic acid methyl ester (0.2274 g, 0.54 mmol) in dioxane (10 mL) and add lithium hydroxide monohydrate (124 mg, 2.69 mmol) followed by water (5 mL). Stir the reaction at RT overnight, dilute with water (10 mL), and acidify with 1 N HCl. Collect the solid by filtration and wash with water (2×10 mL) and Et2O (2×10 mL). Dry the solid in a vacuum oven to give 0.145 g (66%). LC-MS/ES m/z 410.3 [M+H]+.

1. customthe reaction at RT overnight
2. customCollect the solid
3. filtrationby filtration
4. washwash with water (2×10 mL) and Et2O (2×10 mL)
5. customDry the solid in a vacuum oven
6. customto give 0.145 g (66%)