反应详情

Heat 1-chloro-2-methoxy-4-nitro-benzene (1.0 g, 5.33 mmol) and 1-methylpiperazine (1.33 g, 13.30 mmol) at 100° C. in a sealed tube for 16 h. Cool the mixture to room temperature and partition between dichloromethane (50 mL) and water (50 mL). Separate the organic portion and extract the aqueous portion with dichlorormethane (2×20 mL). Dry the combined organic portions (Na2SO4), filter and concentrate in vacuo to give 1.05 g (78%) of the title compound. MS/ES m/z 252.0 [M+H]+.

1. custompartition between dichloromethane (50 mL) and water (50 mL)
2. customSeparate the organic portion
3. extractionextract the aqueous portion with dichlorormethane (2×20 mL)
4. dry with materialDry the combined organic portions (Na2SO4)
5. filtrationfilter
6. concentrationconcentrate in vacuo