反应详情

Dissolve 1-(2-methoxy-4-nitro-phenyl)-4-methyl-piperazine (1.05 g, 4.18 mmol) in ethyl acetate (50 mL) and add 10% Pd/C (0.20 g). Hydrogenate the slurry at room temperature under a hydrogen filled balloon for 16 h. Filter the slurry through a pad of Celite® and rinse with ethyl acetate. Concentrate the filtrate in vacuo to give a reddish solid (0.66 g, 71% yield). MS/ES m/z 220.0 (M+1)+.

1. filtrationFilter the slurry through a pad of Celite®
2. washrinse with ethyl acetate
3. concentrationConcentrate the filtrate in vacuo