反应详情

温度

0 °C

Dissolve 1-(2-methoxy-phenyl)-piperazine (5.0 g, 26.0 mmol) in dichloromethane 450 mL) and cool to 0° C. Add bromine (4.16 g, 26.0 mmol) slowly dropwise. After 2 h wash the reaction mixture with 1 N sodium hydroxide (250 mL). Separate the organic portion, dry (Na2SO4), filter and concentrate in vacuo to afford 7.0 g (99%) of the title compound. MS/ES m/z (81Br) 273.0 [M+H]+.

1. washAfter 2 h wash the reaction mixture with 1 N sodium hydroxide (250 mL)
2. customSeparate the organic portion
3. dry with materialdry (Na2SO4)
4. filtrationfilter
5. concentrationconcentrate in vacuo