HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2384938Generated: November 1, 2026
1-(2-Methoxyphenyl)piperazine → 1-(4-Bromo-2-methoxyphenyl)piperazine
https://huagongshe.com/reaction/2384938
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-(2-Methoxyphenyl)piperazine | HCID 1346 | — |
| Reactant | Bromine | HCID 24408 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(4-Bromo-2-methoxyphenyl)piperazine | HCID 68948883 | 99.3% |
Reaction Steps
Dissolve 1-(2-methoxy-phenyl)-piperazine (5.0 g, 26.0 mmol) in dichloromethane 450 mL) and cool to 0° C. Add bromine (4.16 g, 26.0 mmol) slowly dropwise. After 2 h wash the reaction mixture with 1 N sodium hydroxide (250 mL). Separate the organic portion, dry (Na2SO4), filter and concentrate in vacuo to afford 7.0 g (99%) of the title compound. MS/ES m/z (81Br) 273.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08263772B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-d0ea6e9fcfc041f58f2edcb5616a2142 |
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| Source note | uspto-grants-2012_09 |
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