Piperidine → HCID 178427515, compound

HRID 2384947Notes

Reaction equation

HRID 2384947 reaction equation
[N:1]1(C(OCC2C3C(=CC=CC=3)C3C2=CC=CC=3)=O)[CH2:48][CH2:47][CH2:46][C@H:2]1[C:3]([N:5]1[CH2:45][CH2:44][CH2:43][C@H:6]1[C:7]([NH:9][C@H:10]([C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])[CH2:11][CH2:12][CH2:13][NH:14][C:15](=[NH:35])[NH:16][S:17]([C:20]1[C:33]([CH3:34])=[C:31]([CH3:32])[C:30]2[O:29][C:26]([CH3:28])([CH3:27])[CH2:25][CH2:24][C:23]=2[C:21]=1[CH3:22])(=[O:19])=[O:18])=[O:8])=[O:4].N1CCCCC1>C(#N)C>[NH:1]1[CH2:48][CH2:47][CH2:46][C@H:2]1[C:3]([N:5]1[CH2:45][CH2:44][CH2:43][C@H:6]1[C:7]([NH:9][C@H:10]([C:36]([O:38][C:39]([CH3:40])([CH3:41])[CH3:42])=[O:37])[CH2:11][CH2:12][CH2:13][NH:14][C:15](=[NH:35])[NH:16][S:17]([C:20]1[C:33]([CH3:34])=[C:31]([CH3:32])[C:30]2[O:29][C:26]([CH3:28])([CH3:27])[CH2:25][CH2:24][C:23]=2[C:21]=1[CH3:22])(=[O:19])=[O:18])=[O:8])=[O:4]

Participants

4

Reactant 2

HCID 8082PiperidineHCID 178427514Fmoc-Pro-Pro-Arg(Pmc)-OtBu

Product 1

HCID 178427515HCID 178427515, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Fmoc-Pro-Pro-Arg(Pmc)-OtBu 1.7 g (1.86 mmol) was dissolved in acetonitrile (50 mL) and treated with piperidine (2 mL) and the mixture was stirred at RT for 4 h. The solvents were removed and the residue was purified by chromatography using methylene chloride-methanol (8:2).

Workup

  1. customThe solvents were removed
  2. customthe residue was purified by chromatography

Sources & evidence

ORD record
ord-1ba3486397394dc5b79b417047b3bd60
Source dataset
uspto-grants-2012_09
Patent number
US08263739B2

Reaction notes

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