3-Nitrobenzenesulfonyl chloride → HCID 2842418, compound

HRID 238497Notes

Reaction equation

HRID 238497 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([S:10](Cl)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH3:14][N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>CCO>[CH3:14][N:15]1[CH2:20][CH2:19][N:18]([S:10]([C:6]2[CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[CH:9]=[CH:8][CH:7]=2)(=[O:12])=[O:11])[CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 84763-Nitrobenzenesulfonyl chlorideHCID 531671-Methylpiperazine

Product 1

HCID 2842418HCID 2842418, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3-nitrobenzenesulfonyl chloride (664 mg, 3.0 mmol) and methylpiperazine (600 mg, 6.0 mmol) in EtOH was stirred for 2 h at RT. The reaction was concentrated and triturated in Et2O to yield a yellowish solid, 3-[(4-methylpiperazinyl) sulfonyl]-1-nitrobenzene, and was used in next step without further purification.

Workup

  1. concentrationThe reaction was concentrated
  2. customtriturated in Et2O

Sources & evidence

ORD record
ord-fe64d686b1c94f37a20a5ac224da023c
Source dataset
uspto-grants-2014_02
Patent number
US08642624B2

Reaction notes

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