HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Fluoropyridine-3-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Fluoronicotinic acid | HCID 96089 | — |
| Product | 2-Fluoropyridine-3-carbonyl chloride | HCID 21959582 | — |
Reaction Steps
2-Fluoropyridine-3-carboxylic acid (7 g, Step C) was suspended in SOCl2 (100 mL). After heating under reflux for 2 h, the mixture became homogeneous. Excess SOCl2 was removed in vacuo to afford a brown solid as desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642624B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-9a43b48ccf53428fb07ec0624f068c33 |
| Source note | uspto-grants-2014_02 |