Benzoate → Benzoate maleate

HRID 2386089Notes

Reaction equation

HRID 2386089 reaction equation
[C:1]([O-:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]([OH:17])(=[O:16])/[CH:11]=[CH:12]\[C:13]([OH:15])=[O:14]>C(OCC)(=O)C>[C:10]([OH:17])(=[O:16])/[CH:11]=[CH:12]\[C:13]([OH:15])=[O:14].[C:1]([OH:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 242BenzoateHCID 444266Maleic Acid

Product 1

HCID 68560292Benzoate maleate

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

In 3 mL of ethyl acetate was dissolved 0.25 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinyl=benzoate, and 0.07 g of maleic acid was added thereto, after which the resulting mixture was heated to effect dissolution. The reaction mixture was cooled and the crystals precipitated were collected by filtration to obtain 0.15 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinyl=benzoate maleate.

Workup

  1. additionwas added
  2. temperatureafter which the resulting mixture was heated
  3. dissolutiondissolution
  4. temperatureThe reaction mixture was cooled
  5. customthe crystals precipitated
  6. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-12d053e06cf242efb9da361bbe32cfde
Source dataset
uspto-grants-2012_09
Patent number
USRE043676E1

Reaction notes

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