2-Bromo-5-(ethylsulfonyl)pyridine → [1,6-Difluoro-4-(5-ethanesulfonyl-pyridin-2-yloxy)-naphthalen-2-yl]-acetic acid
반응식
C[O:2][C:3](=[O:18])[CH2:4][C:5]1[CH:14]=[C:13]([OH:15])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:16])[CH:11]=2)[C:6]=1[F:17].Br[C:20]1[CH:25]=[CH:24][C:23]([S:26]([CH2:29][CH3:30])(=[O:28])=[O:27])=[CH:22][N:21]=1>>[F:17][C:6]1[C:7]2[C:12](=[CH:11][C:10]([F:16])=[CH:9][CH:8]=2)[C:13]([O:15][C:20]2[CH:25]=[CH:24][C:23]([S:26]([CH2:29][CH3:30])(=[O:27])=[O:28])=[CH:22][N:21]=2)=[CH:14][C:5]=1[CH2:4][C:3]([OH:2])=[O:18]참가 물질
3
실험 절차
Starting with (1,6-difluoro-4-hydroxy-naphthalen-2-yl)acetic acid methyl ester (50 mg, 0.198 mmol) and 2-bromo-5-ethanesulfonyl-pyridine (52 mg, 0.208 mmol), using a method analogous to the one described for example 4-1, [1,6-difluoro-4-(5-ethanesulfonyl-pyridin-2-yloxy)-naphthalen-2-yl]-acetic acid (10 mg, 12%) was obtained as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.52 (d, 1H), 8.34 (dd, 1H), 8.19 (dd, 1H), 7.42-7.76 (m, 4H), 3.78-3.86 (m, 2H), 3.37-3.40 (m, 2H), 1.12 (t, 3H); MS cald. for C19H15F2NO5S 407, obsd. (ESI+) [(M+H)+] 408.
출처 및 근거
- ORD 기록
- ord-74adb2804e504766978c87596bc190bb
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08642629B2
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