2-Bromo-5-(ethylsulfonyl)pyridine → [1,6-Difluoro-4-(5-ethanesulfonyl-pyridin-2-yloxy)-naphthalen-2-yl]-acetic acid

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Reaction Steps

Starting with (1,6-difluoro-4-hydroxy-naphthalen-2-yl)acetic acid methyl ester (50 mg, 0.198 mmol) and 2-bromo-5-ethanesulfonyl-pyridine (52 mg, 0.208 mmol), using a method analogous to the one described for example 4-1, [1,6-difluoro-4-(5-ethanesulfonyl-pyridin-2-yloxy)-naphthalen-2-yl]-acetic acid (10 mg, 12%) was obtained as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.52 (d, 1H), 8.34 (dd, 1H), 8.19 (dd, 1H), 7.42-7.76 (m, 4H), 3.78-3.86 (m, 2H), 3.37-3.40 (m, 2H), 1.12 (t, 3H); MS cald. for C19H15F2NO5S 407, obsd. (ESI+) [(M+H)+] 408.

Provenance & Evidence