HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2386178Generated: October 29, 2026
Water → N-(5-(furan-2-yl)-4-methylthiazol-2-yl)acetamide
https://huagongshe.com/reaction/2386178
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,2-Dimethoxyethane | HCID 8071 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide | HCID 822437 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | N-(5-(furan-2-yl)-4-methylthiazol-2-yl)acetamide | HCID 59362180 | — |
Reaction Steps
A mixture of N-(5-bromo-4-methylthiazol-2-yl)acetamide (4 g), furan-2-yl-2-boronic acid (4.22 g), tetrakis(triphenylphosphine)palladium (1.8 g) and 2 N sodium carbonate (36 ml) in DME (60 ml) was stirred at 95° C. for 18 h. After cooling, water (100 ml) was added. Extraction with ethyl acetate (3×80 ml), drying, concentration and purification (SiO2, 0 to 100% ethyl acetate in hexane) gave pure N-(5-(furan-2-yl)-4-methylthiazol-2-yl)acetamide (2.95 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08268818B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-ed6612c653dd4662aa8033b0eedf27e3 |
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| Source note | uspto-grants-2012_09 |
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