Lamotrigine → HCID 24771271, compound

HRID 2386199Notes

Reaction equation

HRID 2386199 reaction equation
CS(OC)(=O)=O.[NH2:7][C:8]1[N:9]=[N:10][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:16]=2[Cl:22])=[C:12]([NH2:14])[N:13]=1.[CH3:23]N(C)C=O>C1(C)C=CC=CC=1>[NH2:14][C:12]1[C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:16]=2[Cl:22])=[N:10][N:9]([CH3:23])[C:8](=[NH:7])[N:13]=1

Participants

5

Reactant 3

HCID 3878LamotrigineHCID 4156Methyl MethanesulfonateHCID 6228Dimethylformamide

Product 1

HCID 24771271HCID 24771271, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
100 °C

Procedure

Methyl methanesulfonate (0.50 g, 4.5 mmol), 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (0.50 g, 2.0 mmol) and dimethylformamide (4 ml) were stirred and heated at 100° C. for 10 min. The solution was cooled, toluene (20 ml) added, and the mixture stirred for 0.5 h. The solid was collected by filtration and recrystallised from propan-2-ol to give the methanesulfonate salt of the title compound as a white solid (0.40 g), mp 274-276° C.

Workup

  1. temperatureThe solution was cooled
  2. filtrationThe solid was collected by filtration
  3. customrecrystallised from propan-2-ol

Sources & evidence

ORD record
ord-9ac4fbf79d674097b3de6f0380cf0e09
Source dataset
uspto-grants-2012_09
Patent number
US08268823B2

Reaction notes

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