Sodium Hydroxide → HCID 57828142, compound

HRID 2386209Notes

Reaction equation

HRID 2386209 reaction equation
[CH2:1]([O:8][C:9]1[C:10]2[CH2:11][N:12]([CH2:33][C:34]([O:36]C)=[O:35])[CH2:13][CH2:14][N:15]([CH2:28][C:29]([O:31]C)=[O:30])[CH2:16][CH2:17][N:18]([CH2:24][C:25]([OH:27])=[O:26])[CH2:19][C:20]([N:23]=2)=[CH:21][CH:22]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[CH2:1]([O:8][C:9]1[C:10]2[CH2:11][N:12]([CH2:33][C:34]([OH:36])=[O:35])[CH2:13][CH2:14][N:15]([CH2:28][C:29]([OH:31])=[O:30])[CH2:16][CH2:17][N:18]([CH2:24][C:25]([OH:27])=[O:26])[CH2:19][C:20]([N:23]=2)=[CH:21][CH:22]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69018474HCID 69018474, compound

Product 1

HCID 57828142HCID 57828142, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

9 g (0.0170 mol) of the methyl ester of (12-benzyloxy-6,9-bis(methoxy-carbonylmethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(14),11(15),12-trien-3-yl)acetic acid are added to a solution of 50 ml of methanol and 50 ml of 5N NaOH. The combined mixture is brought to reflux for 6 h. After concentrating and neutralizing by passing through IRC50 resin, the product is hardened in isopropanol. White crystals are obtained. w=8 g.

Workup

  1. temperatureto reflux for 6 h
  2. concentrationAfter concentrating
  3. customWhite crystals are obtained

Sources & evidence

ORD record
ord-6401dad11c0e4ecfaa7f51c36c9a2f9e
Source dataset
uspto-grants-2012_09
Patent number
US08268810B2

Reaction notes

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