Sodium Hydroxide → HCID 57828142, compound

Participants

Reaction Steps

9 g (0.0170 mol) of the methyl ester of (12-benzyloxy-6,9-bis(methoxy-carbonylmethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(14),11(15),12-trien-3-yl)acetic acid are added to a solution of 50 ml of methanol and 50 ml of 5N NaOH. The combined mixture is brought to reflux for 6 h. After concentrating and neutralizing by passing through IRC50 resin, the product is hardened in isopropanol. White crystals are obtained. w=8 g.

Provenance & Evidence