(4-Benzyloxy-6-fluoro-1-methyl-naphthalen-2-yl)-acetic acid methyl ester → (6-Fluoro-4-hydroxy-1-methyl-naphthalen-2-yl)acetic acid methyl ester

Participants

Reaction Steps

To a solution of (4-benzyloxy-6-fluoro-1-methyl-naphthalen-2-yl)-acetic acid methyl ester (50 mg) in methanol was added 10% palladium on carbon (10 mg). After being stirred at room temperature under a hydrogen atmosphere overnight, the resulting mixture was filtered. The filtrate was concentrated in vacuo to afford (6-fluoro-4-hydroxy-1-methyl-naphthalen-2-yl)-acetic acid methyl ester (30 mg) as a white solid.

Provenance & Evidence