Methyl 4-benzyl-3-methylmorpholine-3-carboxylate → Methyl 3-methylmorpholine-3-carboxylate

HRID 2386241Notes

Reaction equation

HRID 2386241 reaction equation
C([N:8]1[CH2:13][CH2:12][O:11][CH2:10][C:9]1([CH3:18])[C:14]([O:16][CH3:17])=[O:15])C1C=CC=CC=1>CCO.[Pd]>[CH3:18][C:9]1([C:14]([O:16][CH3:17])=[O:15])[CH2:10][O:11][CH2:12][CH2:13][NH:8]1

Participants

4

Reactant 1

HCID 67268304Methyl 4-benzyl-3-methylmorpholine-3-carboxylate

Product 1

HCID 67268303Methyl 3-methylmorpholine-3-carboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Dissolve methyl 4-benzyl-3-methylmorpholine-3-carboxylate in EtOH (10 volumes) and add 10% Pd/C (0.1 eq.). Hydrogenate for 16 hours, filter through Celite®, and concentrate to give the title compound.

Workup

  1. filtrationfilter through Celite®
  2. concentrationconcentrate

Sources & evidence

ORD record
ord-6d34390c0fae4263937b91c0e0f08259
Source dataset
uspto-grants-2012_09
Patent number
US08268819B2

Reaction notes

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