Methanesulfonyl chloride → (3-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-methanesulfonyl-amino}-propyl)-carbamic acid tert-butyl ester

HRID 2386300노트

반응식

HRID 2386300 반응식
[C:1]([O:5][C:6](=[O:26])[NH:7][CH2:8][CH2:9][CH2:10][NH:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]2[CH:24]=[CH:23][N:22]=[C:21]([Cl:25])[N:20]=2)[CH:14]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:27][S:28](Cl)(=[O:30])=[O:29]>>[C:1]([O:5][C:6](=[O:26])[NH:7][CH2:8][CH2:9][CH2:10][N:11]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]2[CH:24]=[CH:23][N:22]=[C:21]([Cl:25])[N:20]=2)[CH:14]=1)[S:28]([CH3:27])(=[O:30])=[O:29])([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 86603243{3-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-propyl}-carbamic acid tert-butyl ester

생성물 1

HCID 86603242(3-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-methanesulfonyl-amino}-propyl)-carbamic acid tert-butyl ester

실험 절차

Intermediate 2 from above was treated with methanesulfonyl chloride following procedure D. LC-MS showed the product had the expected M+H+ of 456.

출처 및 근거

ORD 기록
ord-e82a31e58c8440abbe1f0de6fc321f26
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08268822B2

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