2-(Pyridin-3-yl)ethan-1-amine → N-(3-(2-chloropyrimidin-4-yl)benzyl)-2-(pyridine-3-yl)ethanamine

HRID 2386368Notes

Reaction equation

HRID 2386368 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH:11]=O)[CH:5]=[CH:4][N:3]=1.[N:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][CH2:23][NH2:24])[CH:17]=1>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH2:11][NH:24][CH2:23][CH2:22][C:18]2[CH:17]=[N:16][CH:21]=[CH:20][CH:19]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 8540512-(Pyridin-3-yl)ethan-1-amineHCID 249019653-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

Product 1

HCID 86603256N-(3-(2-chloropyrimidin-4-yl)benzyl)-2-(pyridine-3-yl)ethanamine

Procedure

Intermediate 1 was coupled with 2-pyridin-3-yl-ethylamine following procedure B. LC-MS showed the product had the expected M+H+ of 325.

Sources & evidence

ORD record
ord-0a4fa57ee4f647a4bb16ae531006009d
Source dataset
uspto-grants-2012_09
Patent number
US08268822B2

Reaction notes

Loading…