2,4-Dichloropyrimidine → 2-Chloro-4-(4-isobutyl-phenyl)-pyrimidine

HRID 2386417Notes

Reaction equation

HRID 2386417 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH2:9]([C:13]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15][CH:14]=1)[CH:10]([CH3:12])[CH3:11]>>[Cl:1][C:2]1[N:7]=[C:6]([C:16]2[CH:17]=[CH:18][C:13]([CH2:9][CH:10]([CH3:12])[CH3:11])=[CH:14][CH:15]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 775312,4-DichloropyrimidineHCID 2773472(4-Isobutylphenyl)boronic acid

Product 1

HCID 249019832-Chloro-4-(4-isobutyl-phenyl)-pyrimidine

Procedure

2,4 dichloropyrimidine was coupled with 4-isobutylphenylboronic acid following procedure A. LC-MS showed the product had the expected M+H+ of 247.

Sources & evidence

ORD record
ord-02832a149ede480bbfc812b918e1fc09
Source dataset
uspto-grants-2012_09
Patent number
US08268822B2

Reaction notes

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