反应详情

温度

10 °C

To a 1000 mL round bottom flask containing a solution of hydrazine monohydrate (280 mL, 4.89 mol) in ethanol (300 mL) is added 3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine (60 g, 308.3 mmol) at 4° C. The resulting clear solution is heated to reflux for 18 h, and then cooled to 10° C. The product precipitated is collected by filtration and dried under vacuum to give the title compound as a white solid (53 g, 90.4%) and is used as is.

1. temperatureThe resulting clear solution is heated
2. temperatureto reflux for 18 h
3. customThe product precipitated
4. filtrationis collected by filtration
5. customdried under vacuum