Hydrochloric Acid → HCID 66955246, compound

HRID 2386659Notes

Reaction equation

HRID 2386659 reaction equation
[ClH:1].C(OC(=O)[NH:8][CH:9]1[CH2:14][CH2:13][CH:12]([C:15]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[O:16])[CH2:11][CH2:10]1)(C)(C)C>CO>[ClH:1].[NH2:8][CH:9]1[CH2:14][CH2:13][CH:12]([C:15]([N:17]2[CH2:18][CH2:19][O:20][CH2:21][CH2:22]2)=[O:16])[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66955430HCID 66955430, compound

Product 1

HCID 66955246HCID 66955246, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

HCl (2 M aq, 150 mL) was added to a suspension of [4-(morpholine-4-carbonyl)-cyclohexyl]-carbamic acid tert-butyl ester (5.8 g) in MeOH, and the resulting mixture was stirred at RT overnight. The reaction mixture was evaporated under reduced pressure, the oily residue was taken up in EtOAc, and the resulting mixture was sonicated. The solid formed was collected by filtration and dried under reduced pressure to afford 5.2 g of (4-amino-cyclo-hexyl)-morpholin-4-yl-methanone hydrochloride.

Workup

  1. customThe reaction mixture was evaporated under reduced pressure
  2. customthe resulting mixture was sonicated
  3. customThe solid formed
  4. filtrationwas collected by filtration
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-5c0042d986e144c2a4f79ecd5af0673f
Source dataset
uspto-grants-2012_09
Patent number
US08268840B2

Reaction notes

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