2H-1,4-Benzoxazin-3(4H)-one,4-methyl- → HCID 66697375, compound

HRID 2386712Notes

Reaction equation

HRID 2386712 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[C:4]([Cl:12])[CH:3]=1.[CH3:13][N:14]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[O:17][CH2:16][C:15]1=[O:24].[Al+3].[Cl-].[Cl-].[Cl-]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:21]2[CH:22]=[CH:23][C:18]3[O:17][CH2:16][C:15](=[O:24])[N:14]([CH3:13])[C:19]=3[CH:20]=2)=[O:11])=[C:4]([Cl:12])[CH:3]=1

Participants

4

Reactant 3

HCID 890322H-1,4-Benzoxazin-3(4H)-one,4-methyl-HCID 6451240Aluminum(III) ChlorideHCID 53403617(4-Bromo-2-chlorophenyl)acetic acid

Product 1

HCID 66697375HCID 66697375, compound

Procedure

In analogy to Example 1, step 1, (4-bromo-2-chloro-phenyl)-acetic acid was converted to the acid chloride and subsequently reacted with 4-methyl-2H-1,4-benzoxazin-3(4H)-one in the presence of AlCl3 to give the title compound as a light brown solid. MS (m/e, ISP neg. ion)=392.1 [M−H+].

Sources & evidence

ORD record
ord-ba333a086d404fc28cad94cca64d75d8
Source dataset
uspto-grants-2012_09
Patent number
US08268820B2

Reaction notes

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