反应详情

温度

100 °C

To a solution of thioisonicotinamide (0.5 g, 3.6 mmol) in 1-methyl-2-pyrrolidinone (25 mL) was added 2-chloro-1-(4,5-dihydro-5-phenyl-3-isoxazolyl)ethanone (0.807 g, 3.6 mmol), at room temperature. The reaction mixture was then heated to 100° C. for 3 h. Then the reaction mixture was cooled to room temperature, quenched with water (100 mL), extracted with ethyl acetate (50 mL×2). The reaction mixture was diluted with water (50 mL) and brine (50 mL), and the organic layer was concentrated under reduced pressure and purified by medium-pressure liquid chromatography using 2% of methanol in chloroform as eluant to give 0.7 g of the title compound as a brown solid.

1. customat room temperature
2. temperatureThen the reaction mixture was cooled to room temperature
3. customquenched with water (100 mL)
4. extractionextracted with ethyl acetate (50 mL×2)
5. additionThe reaction mixture was diluted with water (50 mL) and brine (50 mL)
6. concentrationthe organic layer was concentrated under reduced pressure
7. custompurified by medium-pressure liquid chromatography