Ammonium Chloride → HCID 23151228, compound

2-bromo-1-(3-chloropropoxy)-4-nitrobenzene (1.3 g), ammonium chloride (1.3 g) and iron (1.3 g) were added to a mixed solvent of methanol (8 mL) and distilled water (4 mL), and the mixture was heated under reflux for 2 hours. The reaction mixture was filtered through cerite, and the filtrate was concentrated. The residue was dissolved in ethyl acetate, and washed with distilled water and saturated brine. The organic phase was dried with anhydrous sodium sulfate, concentrated and dried to obtain the target substance (0.92 g).

1. distillationdistilled water (4 mL)
2. temperaturethe mixture was heated
3. temperatureunder reflux for 2 hours
4. filtrationThe reaction mixture was filtered through cerite, and the filtrate
5. concentrationwas concentrated
6. dissolutionThe residue was dissolved in ethyl acetate
7. washwashed with distilled water and saturated brine
8. dry with materialThe organic phase was dried with anhydrous sodium sulfate
9. concentrationconcentrated
10. customdried
11. customto obtain the target substance (0.92 g)

ORD record

ord-979208e33bd844ecb119f028992b57d5

Source dataset

uspto-grants-2012_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08268842B2