Piperidine → HCID 11569010, compound

HRID 2386926Notes

Reaction equation

HRID 2386926 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([N:13]2[C:22](=[O:23])[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=[C:14]2[CH2:24][CH3:25])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH2:10][CH2:11]Cl.[NH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>C(OCC)C>[Br:1][C:2]1[CH:3]=[C:4]([N:13]2[C:22](=[O:23])[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=[C:14]2[CH2:24][CH3:25])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH2:10][CH2:11][N:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 23151397HCID 23151397, compound

Product 1

HCID 11569010HCID 11569010, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
80 °C

Procedure

3-[3-bromo-4-(3-chloropropoxy)phenyl]-2-ethyl -4(3H)-quinazolinone (70 mg) was dissolved in piperidine (1 mL), and stirred at 80° C. for 5 hours. The reaction solution was diluted with diethyl ether, and insoluble matter was filtered off. The filtrate was concentrated, dried under vacuum, and the title compound (80 mg, 99%) was thus obtained as a light yellow solid.

Workup

  1. filtrationwas filtered off
  2. concentrationThe filtrate was concentrated
  3. customdried under vacuum

Sources & evidence

ORD record
ord-c2e7826892a14271aefeeb31383657d8
Source dataset
uspto-grants-2012_09
Patent number
US08268842B2

Reaction notes

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