1-[3-(4-Nitrophenoxy)propyl]piperidine → 4-[3-(1-Piperidinyl)propoxy]aniline

HRID 2386929Notes

Reaction equation

HRID 2386929 reaction equation
[N+:1]([C:4]1[CH:19]=[CH:18][C:7]([O:8][CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:6][CH:5]=1)([O-])=O.[H][H]>CO.[Pd]>[N:12]1([CH2:11][CH2:10][CH2:9][O:8][C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:19][CH:18]=2)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1

Participants

5

Reactant 2

HCID 20579281-[3-(4-Nitrophenoxy)propyl]piperidineHCID 178418361HCID 178418361, compound

Product 1

HCID 219749324-[3-(1-Piperidinyl)propoxy]aniline

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1-[3-(4-nitrophenoxy)propyl]piperidine was dissolved in methanol, and the target compound was obtained by catalytic reduction using a palladium charcoal catalyst in a current of hydrogen.

Workup

  1. customthe target compound was obtained by catalytic reduction

Sources & evidence

ORD record
ord-0062b87a56054e67835b2e093c39bd33
Source dataset
uspto-grants-2012_09
Patent number
US08268842B2

Reaction notes

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