反应详情

温度

120 °C

Employing a known method outlined in patent application WO0189457: 2′-Methoxy-3′-amino-biphenyl-3-carboxylic acid 1e (2.5 g, 10.3 mmol) was dissolved in 100 mL of hydrobromic acid (40%). The reaction mixture was heated to reflux at 120° C. overnight. The mixture was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography to obtain the title compound 3′-amino-2′-hydroxy-biphenyl-3-carboxylic acid hydrobromide 1f (2.4 g, 88.8%) as a khaki solid.

1. temperatureThe reaction mixture was heated
2. concentrationThe mixture was concentrated under reduced pressure
3. customthe resulting residue was purified by silica gel column chromatography