HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutanone → HCID 86600245, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutanone | HCID 14496 | — |
| Reactant | 2-Bromo-4-nitrophenol | HCID 22109 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Product | HCID 86600245 | HCID 86600245 | — |
Reaction Steps
3-bromo-4-[(1-cyclobutylpiperidin-4-yl)oxy]aniline was obtained according to the method of Example 94, using 2-bromo-4-nitrophenol, N-Boc-4-piperidinol and cyclobutanone as starting materials. By treating this with 1 Eq of p-toluenesulfonic acid monohydrate, the target compound was obtained as a colorless solid. 2-bromo-4-nitrophenol was manufactured by the method described in the literature (J. Org. Chem., Vol. 62, 1997, p. 4504).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268842B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-00c8959156f14d9e8f8d56af056367ce |
| Source note | uspto-grants-2012_09 |