2-Amino-4-chloropyrimidine → HCID 68603550, compound

HRID 2386979Notes

Reaction equation

HRID 2386979 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]([CH3:12])[C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8].Cl[C:14]1[CH:19]=[CH:18][N:17]=[C:16]([NH2:20])[N:15]=1>>[NH2:20][C:16]1[N:17]=[C:18]([NH:1][CH2:2][CH2:3][N:4]([CH3:12])[C:5](=[O:11])[O:6][C:7]([CH3:8])([CH3:9])[CH3:10])[CH:19]=[CH:14][N:15]=1

Participants

3

Reactant 2

HCID 2233322-Amino-4-chloropyrimidineHCID 2756424N-Boc-N-methylethylenediamine

Product 1

HCID 68603550HCID 68603550, compound

Procedure

tert-Butyl 2-aminoethyl(methyl)carbamate (337 mg, 1.93 mmol) and 4-chloropyrimidin-2-amine (260 mg, 2.01 mmol) were combined under the conditions described in Example 1D to afford tert-butyl 2-[(2-aminopyrimidin-4-yl)amino]ethyl(methyl)carbamate. MS (M+H)+ m/z 268.3. The intermediate was treated under the conditions of Example 1E to afford the title compound. MS (ESI+) m/z 167.9 (M+H)+.

Sources & evidence

ORD record
ord-83b3790fa846443a8fe940fe21478853
Source dataset
uspto-grants-2012_09
Patent number
US08268846B2

Reaction notes

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