反应详情

A solution of 2,2-dimethyl-N-[3-(pyridine-3-carbonyl)-pyridin-2-yl]-propionamide (0.225 g, 0.79 mmol) in 3M HCl (10 ml) is heated at reflux for 4 hours. The reaction mixture is allowed to cool to room temperature and the pH adjusted to basic with 2M NaOH. The product is extracted into DCM, dried (MgSO4), and concentrated in vacuo to afford a yellow solid. Drying in vacuo at 45° C. overnight yields (2-Amino-pyridin-3-yl)-pyridin-3-yl-methanone [M+H]+ 200.

1. temperatureat reflux for 4 hours
2. extractionThe product is extracted into DCM
3. dry with materialdried (MgSO4)
4. concentrationconcentrated in vacuo
5. customto afford a yellow solid
6. customDrying in vacuo at 45° C. overnight