Sodium Acetate → HCID 68500140, compound

HRID 2387229Notes

Reaction equation

HRID 2387229 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([CH2:8][C:9]2[CH:10]=[CH:11][C:12]([F:17])=[C:13]([CH:16]=2)[C:14]#[N:15])=[C:4]([CH3:18])[C:3]=1[CH3:19].CC([O-])=[O:22].[Na+]>C(O)(=O)C>[CH3:18][C:4]1[C:5]([CH2:8][C:9]2[CH:10]=[CH:11][C:12]([F:17])=[C:13]([CH:16]=2)[C:14]#[N:15])=[N:6][NH:7][C:2](=[O:22])[C:3]=1[CH3:19]

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 86632300HCID 86632300, compound

Product 1

HCID 68500140HCID 68500140, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of intermediate B2 in acetic acid (0.16 M) was added NaOAc (2 eq.) and the mixture was stirred and heated to reflux for 1 h. The solution was cooled to RT and the solvent was removed under reduced pressure. The residue was suspended in water and triturated until a fine suspension was obtained. The solid material was filtered off, washed with water, dried by air stream and then under high vacuum. MS (ES) C14H12FN3O required: 257, found: 258 (M+H)+.

Workup

  1. temperatureheated
  2. temperatureto reflux for 1 h
  3. customthe solvent was removed under reduced pressure
  4. customtriturated until a fine suspension
  5. customwas obtained
  6. filtrationThe solid material was filtered off
  7. washwashed with water
  8. customdried by air stream

Sources & evidence

ORD record
ord-0bfa102175f34410babe66ad6f646631
Source dataset
uspto-grants-2012_09
Patent number
US08268827B2

Reaction notes

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