Hydrochloric Acid → HCID 68502767, compound

HRID 2387230Notes

Reaction equation

HRID 2387230 reaction equation
[CH3:1][C:2]1[C:3]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([F:19])=[C:15]([CH:18]=2)[C:16]#N)=[N:4][NH:5][C:6](=[O:9])[C:7]=1[CH3:8].[OH-:20].[Na+].Cl.[OH2:23]>>[CH3:1][C:2]1[C:3]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([F:19])=[C:15]([CH:18]=2)[C:16]([OH:23])=[O:20])=[N:4][NH:5][C:6](=[O:9])[C:7]=1[CH3:8]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 68500140HCID 68500140, compound

Product 1

HCID 68502767HCID 68502767, compound

Conditions

Temperature
100 °C

Procedure

To a suspension of intermediate B3 in water (0.35 M) was added NaOH (8 eq.) and the resulting mixture was stirred and heated to 100° C. for 60 min. The mixture was cooled with an ice bath and slowly acidified to pH 2-3 with 6N HCl. The formed light yellow precipitate was filtered off, dried under air stream and then under high vacuum. MS (ES) C14H13FN2O3 required: 276, found: 277 (M+H)+.

Workup

  1. temperatureThe mixture was cooled with an ice bath
  2. filtrationThe formed light yellow precipitate was filtered off
  3. customdried under air stream

Sources & evidence

ORD record
ord-07342cc81e1a421989ed54ae98cc1b12
Source dataset
uspto-grants-2012_09
Patent number
US08268827B2

Reaction notes

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