Pyridine → N-(2,4-difluorophenyl)propane-2-sulfonamide

HRID 2387279Notes

Reaction equation

HRID 2387279 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH2:9].N1C=CC=CC=1.[CH3:16][CH:17]([S:19](Cl)(=[O:21])=[O:20])[CH3:18].CN(C1C=CC=CN=1)C>C(Cl)Cl.O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][S:19]([CH:17]([CH3:18])[CH3:16])(=[O:21])=[O:20]

Participants

7

Reactant 4

HCID 1049PyridineHCID 97092,4-DifluoroanilineHCID 218852-DimethylaminopyridineHCID 824082-Propanesulfonyl chloride

Product 1

HCID 58087510N-(2,4-difluorophenyl)propane-2-sulfonamide

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
45 °C

Procedure

To 2,4-difluoro-phenylamine (47, 4.0 mL, 40.0 mmol) in methylene chloride (50 mL) were added pyridine (3.37 mL, 42.3 mmol), propane-2-sulfonyl chloride (6.00 g, 42.3 mmol) and dimethylaminopyridine (0.20 g, 1.64 mmol) under an atmosphere of nitrogen. The reaction was stirred at 45° C. overnight. The reaction was poured into water and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated and purified by silica gel column chromatography 3% methanol in methylene chloride to give a white solid (48, 8.0 g, 85%). MS (ESI) [M−H+]−=234.0.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated
  6. custompurified by silica gel column chromatography 3% methanol in methylene chloride
  7. customto give a white solid (48, 8.0 g, 85%)

Sources & evidence

ORD record
ord-ae14eeb3ba914045ba37793a150bc8bc
Source dataset
uspto-grants-2012_09
Patent number
US08268858B2

Reaction notes

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