Thionyl Chloride → 1-Chloro-6-(trifluoromethyl)indane

HRID 2387435Notes

Reaction equation

HRID 2387435 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][CH:9]2O)=[CH:5][CH:4]=1.S(Cl)([Cl:17])=O>>[Cl:17][CH:9]1[C:10]2[C:6](=[CH:5][CH:4]=[C:3]([C:2]([F:14])([F:13])[F:1])[CH:11]=2)[CH2:7][CH2:8]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 592126636-(Trifluoromethyl)-2,3-dihydro-1H-inden-1-OL

Product 1

HCID 592126531-Chloro-6-(trifluoromethyl)indaneYield 90%

Procedure

6-(Trifluoromethyl)indan-1-ol (1.52 g, 7.5 mmol) was dissolved in thionyl chloride (15 mL). After being stirred at room temperature for 2 hrs, the solution was concentrated in vacuo to provide the title compound (1.5 g, 90%).

Workup

  1. concentrationthe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-e7f963864f1143e98eaacb76a9265e05
Source dataset
uspto-grants-2012_09
Patent number
US08268826B2

Reaction notes

Loading…