反应详情

温度

70 °C

To a solution of 1-(2,2-dimethoxyethyl)-5-iodo-1H-indazole (920 mg, 2.77 mmol) in THF (20 mL) at 40° C. was added 2M HCl (20 mL). The solution was heated at 70° C. for 18 h. The reaction mixture was cooled and diluted with H2O (60 mL). The aqueous mixture was extracted with EtOAc (3×50 mL), dried over Na2SO4 and concentrated to yield the title compound (737 mg, 88%) as a light brown solid: ESI MS m/z 318 [M+H]+.

1. temperatureThe reaction mixture was cooled
2. extractionThe aqueous mixture was extracted with EtOAc (3×50 mL)
3. dry with materialdried over Na2SO4
4. concentrationconcentrated