Hydroxyamine hydrochloride → HCID 136065378, compound

HRID 2387713Notes

Reaction equation

HRID 2387713 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Br:10])[N:5]=1)(=O)[CH3:2].Cl.[NH2:12][OH:13]>N1C=CC=CC=1>[Br:10][C:6]1[N:5]=[C:4](/[C:1](=[N:12]\[OH:13])/[CH3:2])[CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 112985782-Acetyl-6-bromopyridine

Product 1

HCID 136065378HCID 136065378, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 2-acetyl-6-bromopyridine (10.0 g, 0.050 mol) and hydroxylamine hydrochloride (6.90 g, 0.10 mol) in pyridine (50 mL) was stirred at room temperature overnight. The solvent was removed under reduced pressure, and the residue was diluted with ethyl acetate (200 mL), washed with water (100 mL), and dried over anhydrous sodium sulfate. Concentration under reduced pressure afforded a 10.75 g of A461.1 as an off-white solid.

Workup

  1. customThe solvent was removed under reduced pressure
  2. additionthe residue was diluted with ethyl acetate (200 mL)
  3. washwashed with water (100 mL)
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationConcentration under reduced pressure
  6. customafforded a 10.75 g of A461.1 as an off-white solid

Sources & evidence

ORD record
ord-a7f62be5e1b349559ce3355e664fec1d
Source dataset
uspto-grants-2012_09
Patent number
US08268855B2

Reaction notes

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