5-(benzyloxy)-3-(methoxymethyl)-2,6-dimethylpyrimidin-4(3H)-one → 5-hydroxy-3-(methoxymethyl)-2,6-dimethylpyrimidin-4(3H)-one

HRID 2387750Notes

Reaction equation

HRID 2387750 reaction equation
C([O:8][C:9]1[C:10](=[O:20])[N:11]([CH2:17][O:18][CH3:19])[C:12]([CH3:16])=[N:13][C:14]=1[CH3:15])C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[C].[Pd]>[OH:8][C:9]1[C:10](=[O:20])[N:11]([CH2:17][O:18][CH3:19])[C:12]([CH3:16])=[N:13][C:14]=1[CH3:15]

Participants

5

Reactant 2

HCID 672837945-(benzyloxy)-3-(methoxymethyl)-2,6-dimethylpyrimidin-4(3H)-oneHCID 178418361HCID 178418361, compound

Product 1

HCID 672821145-hydroxy-3-(methoxymethyl)-2,6-dimethylpyrimidin-4(3H)-oneYield 100.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

The compound 326-4 (1.42 g) was dissolved in ethyl acetate (30 ml). Palladium-carbon (700 mg) was added to the solution, and the obtained mixture was stirred in a hydrogen atmosphere for 1 hour. The reaction mixture was filtered with Celite, and the filtrate was concentrated under reduced pressure, so as to obtain the crude title compound (954 mg).

Workup

  1. filtrationThe reaction mixture was filtered with Celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-5e642718ffdb43dc91d15ba560a443c5
Source dataset
uspto-grants-2012_09
Patent number
US08268848B2

Reaction notes

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