Methanol → 3-(Difluoromethoxy)-2-methoxypyridine

HRID 2387768Notes

Reaction equation

HRID 2387768 reaction equation
[Na].Cl[C:3]1[C:8]([O:9][CH:10]([F:12])[F:11])=[CH:7][CH:6]=[CH:5][N:4]=1.[CH3:13][OH:14]>>[F:11][CH:10]([F:12])[O:9][C:8]1[C:3]([O:14][CH3:13])=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 887Methanol2×HCID 5360545SodiumHCID 533020352-Chloro-3-(difluoromethoxy)pyridine

Product 1

HCID 666173823-(Difluoromethoxy)-2-methoxypyridineYield 56%

Conditions

Temperature
100 °C

Procedure

As shown in step 3-ii of Scheme 3, an excess of sodium metal was dissolved into 20 mL anhydrous methanol and 2-chloro-3-(difluoromethoxy)pyridine (2.0 g, 11.1 mmol) in anhydrous methanol was added. The reaction mixture was stirred in a sealed vessel at 100° C. for 6 hours. The volatiles were removed under reduced pressure and the residue was partitioned between EtOAc and brine. The brine was extracted with EtOAc and the combined organics were dried over Na2SO4, filtered, and the volatiles removed under reduced pressure. The product was purified by silica gel chromatography (DCM) to yield 3-(difluoromethoxy)-2-methoxypyridine as a colorless oil (Compound 1007, 1.1 g, 56% yield: ESMS (M+H) 176.

Workup

  1. additionwas added
  2. customThe volatiles were removed under reduced pressure
  3. customthe residue was partitioned between EtOAc and brine
  4. extractionThe brine was extracted with EtOAc
  5. dry with materialthe combined organics were dried over Na2SO4
  6. filtrationfiltered
  7. customthe volatiles removed under reduced pressure
  8. customThe product was purified by silica gel chromatography (DCM)

Sources & evidence

ORD record
ord-ab2c12110523414880620e12da0e4fee
Source dataset
uspto-grants-2012_09
Patent number
US08268999B2

Reaction notes

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