Pentylamine → HCID 68415787, compound

HRID 2387772Notes

Reaction equation

HRID 2387772 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.[CH2:10]([NH2:15])[CH2:11][CH2:12][CH2:13][CH3:14]>O1CCOCC1>[CH3:9][C:4]1[N:3]=[C:2]([NH2:1])[N:7]=[C:6]([NH:15][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH:5]=1

Participants

4

Reactant 2

HCID 8060PentylamineHCID 218102-Amino-4-chloro-6-methylpyrimidine

Product 1

HCID 68415787HCID 68415787, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2-Amino-4-chloro-6-methylpyrimidine (10 g) and pentylamine (20 ml) were combined in dioxane (100 mL) and refluxed for 42 h. The solvents were evaporated, the product taken up in DCM, washed with water, sat. sodium bicarbonate solution, brine, dried, and the solvent evaporated to give the subtitle compound 8.3 g.

Workup

  1. temperaturerefluxed for 42 h
  2. customThe solvents were evaporated
  3. washwashed with water, sat. sodium bicarbonate solution, brine
  4. customdried
  5. customthe solvent evaporated

Sources & evidence

ORD record
ord-190a6037f4744643a691018ca798b579
Source dataset
uspto-grants-2012_09
Patent number
US08268990B2

Reaction notes

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