HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → Methyl 2-(3-((N-(3-(2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Methyl 2-(3-((N-(3-(2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)propyl)-2-chloroacetamido)methyl)phenyl)acetate | HCID 68952086 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-(3-((N-(3-(2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate | HCID 42614031 | — |
Reaction Steps
The product from step (i) (0.1 g) was dissolved in MeOH and dimethylamine (2M in MeOH, 0.61 ml) was added. The reaction mixture was stirred for 72 h at rt, the solvents were evaporated and the residue purified by RPHPLC to give the title compound 24 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268990B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-fd72f57dc2ac41708b6294eab91f9a2e |
| Source note | uspto-grants-2012_09 |