反应详情

To a solution of valeraldehyde (5.81 g) in THF (100 mL) was added tert-butoxycarbonylmethylenetriphenylphosphorane (25.4 g) and the reaction mixture stirred for 16 h at rt. The solvents were evaporated, the residue slurried in diethyl ether and filtered. The filtrate was evaporated and the residue purified by chromatography eluting with 3% EtOAc in isohexane to give the subtitle compound 8.5 g.

1. customThe solvents were evaporated
2. filtrationfiltered
3. customThe filtrate was evaporated
4. customthe residue purified by chromatography
5. washeluting with 3% EtOAc in isohexane