Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | (S)-2-(4-((2-Amino-4-(1-hydroxypentan-2-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetic acid | HCID 68953524 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 42613157 | HCID 42613157 | — |
Reaction Steps
Concentrated sulfuric acid (0.3 mL) was added to a solution of the product from step (v) (0.09 g) in MeOH (1 mL). The solution was heated at 70° C. for 3 h and then poured into saturated aqueous NaHCO3 solution (10 mL). The aqueous was extracted with EtOAC and the combined organic phases were dried, filtered and evaporated. The crude product was purified by RPHPLC to give the title compound, 0.007 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08268990B2 |
|---|
| Source dataset | uspto-grants-2012_09 |
|---|
| ORD ID | ord-4bcd1082768f483e975b5ce5d1fc9927 |
|---|
| Source note | uspto-grants-2012_09 |
|---|
