Hydrochloric Acid → (4-((2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)phenyl)methanol

HRID 2387841Notes

Reaction equation

HRID 2387841 reaction equation
Cl.[CH3:2][C:3]1[N:8]=[C:7]([NH2:9])[N:6]=[C:5]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:4]=1[CH2:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][O:24]C2CCCCO2)=[CH:19][CH:18]=1>CO>[NH2:9][C:7]1[N:8]=[C:3]([CH3:2])[C:4]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][OH:24])=[CH:19][CH:18]=2)=[C:5]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 684154226-Methyl-N4-pentyl-5-(4-((tetrahydro-2H-pyran-2-yloxy)methyl)benzyl)pyrimidine-2,4-diamine

Product 1

HCID 68416750(4-((2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)phenyl)methanol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2M HCl (10 ml) was added to a stirred solution of the product from step (iv) (3.4 g) in MeOH (30 ml). The mixture was stirred at rt for 3 days then the solvent evaporated under reduced pressure. The residue was partitioned between DCM/aq NaHCO3 solution, the organics separated, dried and evaporated under reduced pressure to afford the subtitle compound, 2.38 g.

Workup

  1. customthe solvent evaporated under reduced pressure
  2. customThe residue was partitioned between DCM/aq NaHCO3 solution
  3. customthe organics separated, dried
  4. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-8e3adf27cf744ec3992dd9d34a9015ca
Source dataset
uspto-grants-2012_09
Patent number
US08268990B2

Reaction notes

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