反应详情

A mixture of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde (30 g), pentylamine (18.5 ml) and TEA (22 ml) in MeOH (600 ml) were heated under reflux for 3 h then partitioned between EtOAc/water. The organics were separated, washed with water, dried and evaporated under reduced pressure. The residue was triturated with ether/iso-hexane to afford the subtitle compound, 20 g.

1. temperaturewere heated
2. temperatureunder reflux for 3 h
3. customthen partitioned between EtOAc/water
4. customThe organics were separated
5. washwashed with water
6. customdried
7. customevaporated under reduced pressure
8. customThe residue was triturated with ether/iso-hexane