HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pentylamine → 2-Amino-4-chloro-6-(pentylamino)pyrimidine-5-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pentylamine | HCID 8060 | — |
| Reactant | 2-Amino-4,6-dichloropyrimidine-5-carboxaldehyde | HCID 265546 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Amino-4-chloro-6-(pentylamino)pyrimidine-5-carbaldehyde | HCID 86633406 | — |
Reaction Steps
A mixture of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde (30 g), pentylamine (18.5 ml) and TEA (22 ml) in MeOH (600 ml) were heated under reflux for 3 h then partitioned between EtOAc/water. The organics were separated, washed with water, dried and evaporated under reduced pressure. The residue was triturated with ether/iso-hexane to afford the subtitle compound, 20 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268990B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-a1ca2a3cd0794b399c5f3a3f8a5a420d |
| Source note | uspto-grants-2012_09 |