HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxyphenylacetic Acid → 2-(3-((2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)-4-methoxyphenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxyphenylacetic Acid | HCID 7690 | — |
| Reactant | (2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methanol | HCID 68418011 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 2-(3-((2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)-4-methoxyphenyl)acetic acid | HCID 68412943 | — |
Reaction Steps
To the product from step (iii) (0.8 g) in 1M aq HCl (20 ml), 4-methoxyphenylacetic acid (1.8 g) was added and heated under reflux for 48 h. The solvent was evaporated and the residue purified by SCX then by RPHPLC to give the subtitle compound, 164 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08268990B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-c124e5efbc774b818ab2ef702b6b7f99 |
| Source note | uspto-grants-2012_09 |